Synaptic Signaling by All-Trans Retinoic Acid in Homeostatic Synaptic Plasticity

Synaptic Signaling by All-Trans Retinoic Acid in Homeostatic Synaptic Plasticity

Normal brain function requires that the overall synaptic activity in neural circuits be kept constant. Long-term alterations of neural activity lead to homeostatic regulation of synaptic strength by a process known as synaptic scaling. The molecular mechanisms underlying synaptic scaling are largely unknown. Here, we report that all-trans retinoic acid (RA), a well-known developmental morphogen...

Role of retinoic acid signaling in homeostatic synaptic plasticity By

Role of retinoic acid signaling in homeostatic synaptic plasticity Homeostatic synaptic plasticity (HSP) is a form on non-Hebbian plasticity that allows neurons to sense their global level of activity and modulate their own function to keep firing rate within a working range. In particular, chronic elevation or reduction of network activity activates compensatory mechanisms that modulate synapt...

Calcineurin mediates homeostatic synaptic plasticity by regulating retinoic acid synthesis.

Homeostatic synaptic plasticity is a form of non-Hebbian plasticity that maintains stability of the network and fidelity for information processing in response to prolonged perturbation of network and synaptic activity. Prolonged blockade of synaptic activity decreases resting Ca(2+) levels in neurons, thereby inducing retinoic acid (RA) synthesis and RA-dependent homeostatic synaptic plasticit...

Endostatin Is a Trans-Synaptic Signal for Homeostatic Synaptic Plasticity

At synapses in organisms ranging from fly to human, a decrease in postsynaptic neurotransmitter receptor function elicits a homeostatic increase in presynaptic release that restores baseline synaptic efficacy. This process, termed presynaptic homeostasis, requires a retrograde, trans-synaptic signal of unknown identity. In a forward genetic screen for homeostatic plasticity genes, we identified...

Nonglobal homeostatic synaptic plasticity?